XY AND XX
Credit: NY Times Crosswored
Ashish Vengsarkar - May 26, 2011

Can you decipher the title and the following clues to this puzzle?

XYTORY LESSON
TRUST ME ON TXY
XXHEYS KISSES
THE WRIGHT BROTXX
XYPANIC HERITAGE

Answer:

XY = male chromosome = HIS
XX = female chromosome = HERS

HIS AND HERS

HISTORY LESSON
TRUST ME ON THIS
HERSHEY'S KISSES
THE WRIGHT BROTHERS 
HISPANIC HERITAGE